TMS Therapy

TMS Fatigue Explained: What to Expect & How to Cope

Transcranial Magnetic Stimulation (TMS) is an FDA-approved therapy that helps individuals with mental health conditions, including major depression, who have not fully responded to traditional depression treatments. TMS uses magnetic fields delivered through a magnetic coil to stimulate specific areas of the brain associated with mood and emotional regulation.

While TMS therapy is generally safe and well-tolerated, patients may experience side effects. One common concern is TMS fatigue, which can occur after a TMS session or treatment course. This article explains what TMS fatigue is, what to expect during treatment, and practical strategies for managing it.

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What is TMS Fatigue?

TMS fatigue refers to feelings of tiredness, low energy, or drowsiness experienced after  transcranial magnetic stimulation TMS treatment. This side effect is usually temporary and mild, but it can affect daily activities if not properly managed. Fatigue can result from the brain’s response to magnetic pulses that stimulate neurons in specific areas of the brain, particularly those involved in mood regulation.

While most patients tolerate TMS therapy well, TMS therapy side effects can include scalp discomfort, headache, or fatigue. Understanding that fatigue is a common and manageable side effect helps patients prepare for their treatment sessions.

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Why TMS Causes Fatigue

During a TMS session, a magnetic coil is placed near the scalp, delivering brief magnetic pulses to targeted brain regions. These pulses modulate neuronal activity, helping to improve depression symptoms. However, stimulating the brain requires energy, and the neural adjustment can leave patients feeling temporarily drained.

Factors that contribute to transcranial magnetic stimulation fatigue include:

  • The number of treatment sessions completed in a week
  • The intensity of magnetic pulses
  • Individual sensitivity to magnetic fields
  • Pre-existing fatigue from depression or other mental health conditions

Fatigue may appear immediately after a session or build gradually over several treatments. It is often most noticeable in the first few weeks of therapy and tends to lessen as the body adjusts to the stimulation.

Common Side Effects of TMS

Aside from fatigue, patients may experience other common side effects of TMS, including:

  • Scalp discomfort at the site of stimulation
  • Mild headaches
  • Tingling sensations in the head or jaw
  • Temporary lightheadedness

These side effects are generally mild and subside within hours to a day. It is important to report any persistent or severe side effects to the treating clinician, as adjustments to the TMS treatment plan can be made to improve comfort and safety.

What to Expect During a TMS Session

A typical TMS session lasts 20–40 minutes. Patients sit comfortably while the clinician positions the magnetic coil over specific areas of the brain. The device delivers controlled magnetic pulses that stimulate neurons linked to mood and emotional regulation.

During the session, patients may hear clicking sounds, which indicate the magnetic fields are working as intended. The procedure is non-invasive and does not require anesthesia. Most patients can resume normal activities immediately afterward, although mild fatigue after TMS is common.

Managing TMS Fatigue

Managing TMS fatigue involves a combination of self-care strategies, session planning, and lifestyle adjustments. Here are practical tips:

  1. Stay hydrated – Drinking water before and after treatment helps maintain energy levels.
  2. Prioritize rest – Allow time to relax after a session; short naps may help relieve fatigue.
  3. Plan treatment times wisely – Some patients prefer sessions earlier in the day to avoid evening drowsiness.
  4. Balanced nutrition – Eating light, energy-sustaining meals can reduce tiredness.
  5. Track your symptoms – Keeping a journal helps identify patterns and informs adjustments to your treatment plan.
  6. Communicate with your provider – Report persistent fatigue or other side effects of TMS to adjust intensity or frequency if needed.

By incorporating these strategies, most patients can continue therapy with minimal disruption to daily life.

How TMS Helps with Mental Health Conditions

TMS works by targeting specific areas of the brain responsible for mood regulation. In depression, these areas may be underactive. By sending magnetic pulses to these regions, TMS can stimulate neuronal activity and improve depression symptoms.

Over a full course of treatment, typically 4–6 weeks with multiple sessions per week, patients may notice:

  • Increased energy and alertness
  • Improved mood and emotional stability
  • Better ability to focus and handle stress

While TMS fatigue may occur during the early stages, the overall effect of TMS is often increased vitality and reduced depressive symptoms over time.

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Comparing TMS to Other Depression Treatments

Unlike medications, which can have systemic side effects, TMS is localized to targeted brain regions. Some benefits of TMS compared to other depression treatments include:

  • Non-invasive with no anesthesia required
  • Minimal systemic side effects
  • Direct stimulation of brain circuits linked to mood and emotion

TMS treatment side effects are generally mild and transient, making it a valuable option for patients who have not fully responded to other depression treatments.

Final Thoughts on TMS Fatigue and Its Management

TMS therapy is an effective, FDA-approved treatment for individuals with major depression and other mental health conditions who have not fully benefited from traditional therapies.

While TMS fatigue and other TMS therapy side effects can occur, they are generally mild and temporary. Simple strategies such as staying hydrated, resting after sessions, and following your treatment plan can help manage these effects.

By understanding what to expect and working closely with your healthcare provider, you can maximize the benefits of transcranial magnetic stimulation TMS and improve your overall mental health and quality of life.

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Jonathan

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